Description
NAD+ (Nicotinamide Adenine Dinucleotide) – High-Purity Research Chemical
- Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
- CAS Number: 53-84-9
- Synonyms: Beta-Nicotinamide Adenine Dinucleotide, NAD HCl, NAD⁺
What is NAD+?
Nicotinamide Adenine Dinucleotide (NAD⁺) is a critical coenzyme found in all living cells, involved in redox reactions, DNA repair, and energy metabolism. As a central player in cellular health, NAD⁺ supports the function of sirtuins—proteins that regulate aging, mitochondrial function, and gene expression.
Age-related NAD⁺ decline is linked to reduced cellular energy, oxidative stress, and the onset of metabolic and neurodegenerative disorders. Increasing NAD⁺ levels has shown promise in restoring cellular function and delaying markers of aging in preclinical research.
Product Overview: NAD⁺ for Laboratory Research
Our NAD⁺ is a high-purity research chemical formulated for laboratory use only. It is not intended for human or veterinary use. This compound is ideal for research focused on:
Energy metabolism
Cellular redox states
Mitochondrial function
DNA repair mechanisms
Age-related cellular changes
Key Biochemical Roles of NAD⁺
NAD⁺ functions as a co-substrate for key enzyme families:
Sirtuins (SIRTs): NAD⁺-dependent deacetylases regulating gene expression, mitochondrial health, and longevity.
PARPs (Poly ADP-Ribose Polymerases): Enzymes involved in DNA repair and genomic stability.
Dehydrogenases: Enzymes in glycolysis and the citric acid cycle that rely on NAD⁺ for redox reactions.
Additionally, NAD⁺ supports ADP-ribosylation, a post-translational modification vital for cellular signaling, inflammation response, and aging.
NAD⁺ and Cellular Metabolism
NAD⁺ is indispensable for:
Glycolysis
Citric Acid Cycle
Fatty Acid Oxidation
Insulin Sensitivity Regulation
Mitochondrial ATP production
A decline in NAD⁺ can impair these processes, potentially contributing to age-related diseases like Type 2 diabetes, neurodegeneration, and cancer.
NAD⁺ Biosynthesis Pathways
NAD⁺ is synthesized through three primary pathways:
De novo Pathway (Tryptophan-derived)
Preiss–Handler Pathway (Nicotinic acid-based)
Salvage Pathway (Recycling nicotinamide precursors)
Key enzymes like NAMPT and NNMT regulate these pathways and are central to NAD⁺ homeostasis—making them promising therapeutic targets.
Areas of Ongoing Research
NAD⁺ is actively studied in:
Mitochondrial efficiency and bioenergetics
Oxidative stress and redox balance
DNA repair after cellular damage
Stem cell renewal and regenerative capacity
Neuroprotection and cognitive aging
NAD⁺ precursors (NMN, NR) and their influence on intracellular levels
Studies continue to explore the potential of NAD⁺ in anti-aging and metabolic research models.
NAD⁺ and Age-Related Decline
Age-associated NAD⁺ decline has been observed across species. It contributes to:
Mitochondrial dysfunction
Increased DNA damage
Inflammatory responses
Cellular senescence
Research shows that replenishing NAD⁺ may improve biomarkers of aging and support genomic integrity.
NAD⁺ Supplementation – Research Use Only
While NAD⁺ precursors like NMN and NR have gained attention for their potential to increase NAD⁺ levels and support healthy aging, this product is for research use only. Preliminary studies suggest benefits in:
Metabolic health
Mitochondrial performance
Cellular repair mechanisms
Note: Long-term safety in humans has not been established, and supplementation should be approached under strict scientific oversight.
Storage & Stability
Storage: -20°C in a dry, sealed container away from light
Stability: Stable for up to 24 months under recommended conditions
Safety & Handling
This research chemical is intended for laboratory use only. Proper PPE, including gloves and eye protection, should be used. Please consult the Safety Data Sheet (SDS) for full handling guidelines.
Conclusion
NAD⁺ is a cornerstone of cellular energy, longevity, and genomic maintenance. As interest in age-related research intensifies, understanding and manipulating NAD⁺ metabolism may unlock new therapeutic pathways. Ongoing studies aim to deepen our knowledge of its role in aging, DNA repair, and metabolic health.
Disclaimer
This NAD⁺ product is provided by ResearchChemical.com strictly for scientific research purposes. Not for human or animal consumption. Unauthorized use is prohibited.
References:
1. Migaud, M. E., Ziegler, M., & Baur, J. A. (2024). Regulation of and challenges in targeting NAD+ metabolism. Nature Reviews Molecular Cell Biology.
2. Ford, D. (2022). A systems approach to NAD+ restoration. Biochemical Pharmacology.
3. Campbell, J. M. (2022). NAD+ research products and their potential in cognitive function. Nutrients.
4. Abdellatif, M., Bugger, H., & Kroemer, G. (2022). NAD+ and vascular dysfunction: from mechanisms to therapeutic opportunities. Journal of Lipid Research.
5. Yang, Y., & Sauve, A. (2016). NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy. Biochimica et Biophysica Acta (BBA).
6. Hershberger, K. A., Martin, A. S., & Hirschey, M. D. (2017). Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nature Reviews Nephrology.
7. Qin, Y. Y., et al. (2024). NAD+ homeostasis and its role in exercise adaptation: A comprehensive review. Free Radical Biology and Medicine.
8. Amjad, S., Nisar, S., & Bhat, A. A. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism.
