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Original price was: $159.99.$129.99Current price is: $129.99.
Research Chemical products are third-party tested by MZ Biolabs, an independent laboratory based in Arizona. Each batch is analyzed to ensure accuracy, purity, and that all specifications are met.
Nicotinamide Adenine Dinucleotide (NAD⁺) is a crucial coenzyme present in all living cells, playing a vital role in redox reactions, DNA repair, and energy metabolism. As a central player in cellular health, NAD⁺ supports the function of sirtuins—proteins that regulate aging, mitochondrial function, and gene expression.
Age-related NAD⁺ decline is linked to reduced cellular energy, oxidative stress, and the onset of metabolic and neurodegenerative disorders. Increasing NAD⁺ levels has shown promise in restoring cellular function and delaying markers of aging in preclinical research
NAD⁺ functions as a co-substrate for key enzyme families:
Sirtuins (SIRTs): NAD⁺-dependent deacetylases regulating gene expression, mitochondrial health, and longevity.
PARPs (Poly ADP-Ribose Polymerases): Enzymes involved in DNA repair and genomic stability.
Dehydrogenases: Enzymes in glycolysis and the citric acid cycle that rely on NAD⁺ for redox reactions.
Additionally, NAD⁺ supports ADP-ribosylation, a post-translational modification vital for cellular signaling, inflammation response, and aging.
NAD⁺ is indispensable for:
Glycolysis
Citric acid cycle
Fatty acid oxidation
Insulin sensitivity regulation
Mitochondrial ATP production
A decline in NAD⁺ can impair these processes, potentially contributing to age-related diseases like Type 2 diabetes, neurodegeneration, and cancer.
NAD⁺ is synthesized through three primary pathways:
De novo pathway (tryptophan-derived)
Preiss–Handler Pathway (Nicotinic acid-based)
Salvage Pathway (Recycling nicotinamide precursors)
Key enzymes like NAMPT and NNMT regulate these pathways and are central to NAD⁺ homeostasis, making them promising therapeutic targets.
NAD⁺ is actively studied in:
Mitochondrial efficiency and bioenergetics
Oxidative stress and redox balance
DNA repair after cellular damage
Stem cell renewal and regenerative capacity
Neuroprotection and cognitive aging
NAD⁺ precursors (NMN, NR) and their influence on intracellular levels
Studies continue to explore the potential of NAD⁺ in anti-aging and metabolic research models.
Age-associated NAD⁺ decline has been observed across species. It contributes to:
Mitochondrial dysfunction
Increased DNA damage
Inflammatory responses
Cellular senescence
Research indicates that replenishing NAD⁺ may enhance biomarkers of aging and promote genomic integrity.
Storage: -20°C in a dry, sealed container away from light
Stability: Stable for up to 24 months under recommended conditions
This research chemical is intended for laboratory use only. Proper PPE, including gloves and eye protection, should be used. Please refer to the Safety Data Sheet (SDS) for complete handling guidelines.
This NAD⁺ product is provided by ResearchChemical.com strictly for scientific research purposes, not for human or animal consumption. Unauthorized use is prohibited.
Our NAD⁺ is a high-purity research chemical formulated for laboratory use only. It is not intended for human or veterinary use. This compound is ideal for research focused on:
Energy metabolism
Cellular redox states
Mitochondrial function
DNA repair mechanisms
Age-related cellular changes
While NAD⁺ precursors, such as NMN and NR, have gained attention for their potential to increase NAD⁺ levels and support healthy aging, this product is intended for research use only. Preliminary studies suggest benefits in:
Metabolic health
Mitochondrial performance
Cellular repair mechanisms
Note: Long-term safety in humans has not been established, and supplementation should be approached under strict scientific oversight.
1. Migaud, M. E., Ziegler, M., & Baur, J. A. (2024). Regulation of and challenges in targeting NAD+ metabolism. Nature Reviews Molecular Cell Biology.
2. Ford, D. (2022). A systems approach to NAD+ restoration. Biochemical Pharmacology.
3. Campbell, J. M. (2022). NAD+ research products and their potential in cognitive function. Nutrients.
4. Abdellatif, M., Bugger, H., & Kroemer, G. (2022). NAD+ and vascular dysfunction: from mechanisms to therapeutic opportunities. Journal of Lipid Research.
5. Yang, Y., & Sauve, A. (2016). NAD+ metabolism: Bioenergetics, signaling, and manipulation for therapy. Biochimica et Biophysica Acta (BBA).
6. Hershberger, K. A., Martin, A. S., & Hirschey, M. D. (2017). Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nature Reviews Nephrology.
7. Qin, Y. Y., et al. (2024). NAD+ homeostasis and its role in exercise adaptation: A comprehensive review. Free Radical Biology and Medicine.
8. Amjad, S., Nisar, S., & Bhat, A. A. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism.
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Storage: -20°C in a dry, sealed container away from light
Stability: Stable for up to 24 months under recommended conditions
This research chemical is intended for laboratory use only. Proper PPE, including gloves and eye protection, should be used. Please refer to the Safety Data Sheet (SDS) for complete handling guidelines.
This NAD⁺ product is provided by ResearchChemical.com strictly for scientific research purposes, not for human or animal consumption. Unauthorized use is prohibited.
Our NAD⁺ is a high-purity research chemical formulated for laboratory use only. It is not intended for human or veterinary use. This compound is ideal for research focused on:
Energy metabolism
Cellular redox states
Mitochondrial function
DNA repair mechanisms
Age-related cellular changes
While NAD⁺ precursors, such as NMN and NR, have gained attention for their potential to increase NAD⁺ levels and support healthy aging, this product is intended for research use only. Preliminary studies suggest benefits in:
Metabolic health
Mitochondrial performance
Cellular repair mechanisms
Note: Long-term safety in humans has not been established, and supplementation should be approached under strict scientific oversight.
1. Migaud, M. E., Ziegler, M., & Baur, J. A. (2024). Regulation of and challenges in targeting NAD+ metabolism. Nature Reviews Molecular Cell Biology.
2. Ford, D. (2022). A systems approach to NAD+ restoration. Biochemical Pharmacology.
3. Campbell, J. M. (2022). NAD+ research products and their potential in cognitive function. Nutrients.
4. Abdellatif, M., Bugger, H., & Kroemer, G. (2022). NAD+ and vascular dysfunction: from mechanisms to therapeutic opportunities. Journal of Lipid Research.
5. Yang, Y., & Sauve, A. (2016). NAD+ metabolism: Bioenergetics, signaling, and manipulation for therapy. Biochimica et Biophysica Acta (BBA).
6. Hershberger, K. A., Martin, A. S., & Hirschey, M. D. (2017). Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nature Reviews Nephrology.
7. Qin, Y. Y., et al. (2024). NAD+ homeostasis and its role in exercise adaptation: A comprehensive review. Free Radical Biology and Medicine.
8. Amjad, S., Nisar, S., & Bhat, A. A. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism.
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