What Are SARMs? A Scientific Guide to Selective Androgen Receptor Modulators

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Dr. J Reyes
4 min read

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What are SARMs: A Comprehensive guide

Selective androgen receptor modulators, more commonly known as SARMs, have become a focal point in the world of biochemical research. But what are SARMs, and why are they garnering such attention in academic, pharmaceutical, and performance-related studies? In this guide, we break down the mechanisms of SARMs, how they are delivered in liquid and powder forms, and what distinguishes one supplier from another, culminating in why Research Chemical is the trusted choice for high-purity SARMs.

What Are SARMs?

SARMs (selective androgen receptor modulators) are synthetic compounds designed to selectively bind to androgen receptors in various tissues of the body. Unlike traditional anabolic agents such as testosterone or anabolic steroids, SARMs are designed to target specific tissues—such as muscle and bone—while minimizing activity in others, like the liver or prostate.

This selectivity is what makes SARMs so valuable for researchers: they can investigate anabolic-like effects without the wide range of systemic impacts associated with steroid hormones.

Mechanism of Action: How Do SARMs Work?

SARMs function by binding to androgen receptors with high affinity, initiating a conformational change in the receptor that affects gene transcription. Once bound, SARMs selectively activate or suppress the expression of specific genes related to muscle growth, bone density, and other androgen-responsive physiological processes.

What differentiates SARMs from anabolic steroids is this selective activation—SARMs are non-steroidal molecules that do not aromatize into estrogen, nor do they have significant progestogenic effects in most cases. This makes them appealing for researchers aiming to study anabolic pathways with fewer variables and side effects.

Forms of SARMs: Liquid vs. Powder

At Research Chemical, SARMs are offered in both liquid and raw powder forms, allowing researchers flexibility in handling and creating testing models for compounds in a study.

Liquid SARMs

  • Pre-dissolved in carrier solvents: PEG-400

  • Ready for precise measurement and test administration via calibrated droppers

  • Requires no additional preparation

  • Ideal for researchers prioritizing ease of use and consistency

Powder SARMs

  • Offer longer shelf life and higher purity per gram

  • Suitable for laboratories with experience in solubilizing compounds

  • Cost-effective for bulk studies

  • Must be handled with proper lab equipment and safety precautions

Each format has its strengths depending on the goals and resources of the research team.

Variations Between Companies: Why Purity and Testing Matter

Not all SARMs are created equal. A significant challenge in today’s research chemical landscape is inconsistent purity levels, mislabeled products, and insufficient third-party verification.

When evaluating a supplier, consider the following:

  • Is the SARM tested by an independent third-party laboratory?

  • Is there a Certificate of Analysis (COA) available for each batch?

  • Is the compound free from contaminants, fillers, or unlisted excipients?

  • Is the product clearly labeled for research use only?

Too often, companies cut corners with low-grade raw materials, inaccurate concentrations, or a lack of regulatory transparency, compromising the integrity of research outcomes.

Why Buy SARMs from Research Chemical?

At Research Chemical, we specialize in high-purity SARMs and peptides for legitimate research purposes. Here’s what sets us apart:

  • 99%+ Purity Verified by Third-Party Labs
    Each batch is rigorously tested, and we make the COAs publicly available for full transparency.

  • U.S.-Based Bottling and Distribution
    All SARMs are bottled and shipped from our U.S. facility under controlled conditions.

  • Both Liquid and Powder Formats Available
    Researchers can choose the form that fits their protocol and testing models.

  • Tamper-Proof Packaging and Secure Shipping
    Products are sealed for integrity and shipped discreetly with tracking and fast delivery.

  • Dedicated Support for Research Professionals
    We are committed to serving universities, laboratories, and independent researchers with fast communication and reliable service. 

Ready to elevate your research?

Explore our full catalog of SARMs and request COAs today and shop now .

Conclusion

So, what are SARMs? They are highly targeted compounds that allow researchers to explore anabolic and androgenic pathways with far greater specificity than traditional hormones. Understanding how they work, how they are delivered, and how to identify high-quality sources is critical to advancing research.

When precision, purity, and professionalism matter, trust Research Chemical—your source for premium SARMs in both liquid and powder form.

References

  1. Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., … & Yialamas, M. A. (2020). Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 105(3), 686–710.
  2. Dalton, J. T., Taylor, R. P., Mohler, M. L., & Steiner, M. S. (2013). Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancerCurrent opinion in supportive and palliative care7(4), 345-351.
  3. Bhasin, S., & Jasuja, R. (2009). Selective androgen receptor modulators as function promoting therapies. Current Opinion in Clinical Nutrition & Metabolic Care12(3), 232-240.
  4. Narayanan, R., Mohler, M. L., Bohl, C. E., Miller, D. D., & Dalton, J. T. (2008). Selective androgen receptor modulators in preclinical and clinical development. Nuclear receptor signaling6(1), nrs-06010.
  5. Thevis, M., Walpurgis, K., & Thomas, A. (2025). Human Sports Drug Testing: Analytical Challenges and Solutions. Analytical chemistry97(11), 5880-5892.

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